abstract：:The B-cell receptor (BCR) is essential for normal B-cell development and maturation. In an increasing number of B-cell malignancies, BCR signaling is implicated as a pivotal pathway in tumorigenesis. Mechanisms of BCR activation are quite diverse and range from chronic antigenic drive by microbial or viral antigens to...

journal_title：Seminars in cancer biology

authors： Niemann CU,Wiestner A

更新日期：2013-12-01 00:00:00

abstract：:The dysregulation of apoptosis is a key step in developing cancers, and mediates resistance to cancer therapy. Commitment to apoptosis is caused by permeabilization of the outer mitochondrial membrane, a process regulated by the interactions between different proteins of Bcl-2 family. Furthermore, Bcl-2 family protein...

journal_title：Seminars in cancer biology

authors： Yu L,Liu S

更新日期：2013-12-01 00:00:00

abstract：:In this paper, we provide an overview of targeted anticancer therapies with small molecule kinase inhibitors. First, we discuss why a single constitutively active kinase emanating from a variety of aberrant genetic alterations is capable of transforming a normal cell, leading it to acquire the hallmarks of a cancer ce...

journal_title：Seminars in cancer biology

authors： Tsai CJ,Nussinov R

更新日期：2013-08-01 00:00:00

abstract：:Neutrophils in the tumor host may promote tumor progression by enhancing angiogenesis, invasion and metastasis. Granulocytic myeloid-derived suppressor cells (MDSC) share many features with neutrophils. Classically, MDSC are viewed as and defined as immunosuppressive cells. In this article we summarize and critically ...

journal_title：Seminars in cancer biology

authors： Brandau S,Moses K,Lang S

更新日期：2013-06-01 00:00:00

abstract：:Systemic treatment of renal cell carcinoma has changed dramatically since 2007, with the development and approval of six new agents, which target complex molecular pathways regulating tumour angiogenesis and cell proliferation and survival. These treatments have significantly improved survival times in metastatic rena...

journal_title：Seminars in cancer biology

authors： Fisher R,Gore M,Larkin J

更新日期：2013-02-01 00:00:00

abstract：:About a century ago Otto Warburg observed that tumor cells exhibited increased glycolysis despite the presence of oxygen and stated this metabolic shift to glycolysis as the origin of cancer cell. In the meantime it has become clear, that the altered glucose metabolism is only one piece of the tumor metabolome puzzle....

journal_title：Seminars in cancer biology

authors： Gottfried E,Kreutz M,Mackensen A

更新日期：2012-08-01 00:00:00

abstract：:Disseminated tumor cells are present in many patients at diagnosis. At a time when the disseminated disease becomes prominent, patients have already been treated with many cycles of therapy to which their metastases were also exposed. These metastases have genetically evolved from primary tumors. Furthermore, their in...

journal_title：Seminars in cancer biology

authors： Lehembre F,Regenass U

更新日期：2012-06-01 00:00:00

abstract：:Epstein-Barr virus (EBV)-encoded small RNA (EBER) is the most abundant EBV viral transcript and is used as a target molecule to detect EBV-infected cells in tissues by in situ hybridization. EBER is expected to form double-stranded RNA-like structures. The results of the present study show that EBER contributes to onc...

journal_title：Seminars in cancer biology

authors： Takada K

更新日期：2012-04-01 00:00:00

abstract：:Data accumulating during the last two decades suggest that tumorigenesis is held in check by two major intrinsic failsafe mechanisms; apoptosis and cellular senescence. While apoptosis is a programmed cell death process, cellular senescence, which is the focus of this article, is defined as irreversible cell cycle arr...

journal_title：Seminars in cancer biology

authors： Larsson LG

更新日期：2011-12-01 00:00:00

abstract：:Close international collaboration between pediatric oncologists has led to marked improvements in the cure of patients, seen as a long-term overall survival rate of about 80%. Despite this progress, neuroblastoma remains a challenging disease for both clinicians and researchers. Major clinical problems include lack of...

journal_title：Seminars in cancer biology

authors： Øra I,Eggert A

更新日期：2011-10-01 00:00:00

abstract：:System approaches in biology have a long history. We focus here on the thinking of Paul A. Weiss and Ludwig von Bertalanffy, who contributed a great deal towards making the system concept operable in biology in the early 20th century. To them, considering whole living systems, which includes their organisation or orde...

journal_title：Seminars in cancer biology

authors： Drack M,Wolkenhauer O

更新日期：2011-06-01 00:00:00

abstract：:Primary liver cancer is the second most common malignancy, and currently results in 360,000 incident cases, and 350,000 deaths a year in China. For the past four decades, three national surveys on cancer mortality during the periods of 1973-1975, 1990-1992, and 2004-2005 have made it possible to estimate China's past ...

journal_title：Seminars in cancer biology

authors： Chen JG,Zhang SW

更新日期：2011-02-01 00:00:00

abstract：:Liver cancer is the fifth most common cancer and the third most common cause of cancer related death in the world. The recent development of new techniques for the investigations of global change in the gene expression, signaling pathways and wide genome binding has provided novel information for the mechanisms underl...

journal_title：Seminars in cancer biology

authors： Iakova P,Timchenko L,Timchenko NA

更新日期：2011-02-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is among the most frequently occurring cancers and the leading causes of cancer mortality worldwide. Identification of the signaling pathways regulating liver carcinogenesis is critical in developing novel chemoprevention and targeted therapies. Mitogen-activated protein kinases (MAPKs),...

journal_title：Seminars in cancer biology

authors： Min L,He B,Hui L

更新日期：2011-02-01 00:00:00

abstract：:Chronic lymphocytic leukaemia (CLL) is the most common form of lymphoid malignancy in Western countries, accounting for around a quarter of all leukaemias. Evidence from epidemiological and family studies have provided evidence for familial clustering of CLL compatible with inherited genetic predisposition to CLL. Dir...

journal_title：Seminars in cancer biology

authors： Crowther-Swanepoel D,Houlston RS

更新日期：2010-12-01 00:00:00

abstract：:The key molecule for normal B cells is the surface Ig (sIg) of the B-cell receptor, which influences cell behaviour, even after neoplastic transformation. During B-cell maturation, sIg accumulates somatic mutations in the Ig variable region (V) genes and tumours retain these patterns, thereby revealing the point of di...

journal_title：Seminars in cancer biology

authors： Packham G,Stevenson F

更新日期：2010-12-01 00:00:00

abstract：:SINE-VNTR-Alus (SVA) are non-autonomous hominid specific retrotransposons that are associated with disease in humans. SVAs are evolutionarily young and presumably mobilized by the LINE-1 reverse transcriptase in trans. SVAs are currently active and may impact the host through a variety of mechanisms including insertio...

journal_title：Seminars in cancer biology

authors： Hancks DC,Kazazian HH Jr

更新日期：2010-08-01 00:00:00

abstract：:Gene vectors with an untargeted insertion profile have been explored in preclinical models and clinical trials for the transfer of potentially therapeutic genetic information into somatic cells that have a high replicative potential. The gene-modified cell population can be viewed as a genetic mosaic whose complexity ...

journal_title：Seminars in cancer biology

authors： Kustikova O,Brugman M,Baum C

更新日期：2010-08-01 00:00:00

abstract：:Cells adhere to one another and/or to matrices that surround them. Regulation of cell-cell (intercellular) and cell-matrix adhesion is tightly controlled in normal cells, however, defects in cell adhesion are common in the majority of human cancers. Multilateral communication among tumor cells with the extracellular m...

journal_title：Seminars in cancer biology

authors： Bourboulia D,Stetler-Stevenson WG

更新日期：2010-06-01 00:00:00

abstract：:Despite continuous improvements in cancer management, locoregional recurrence or metastatic spread still occurs in a high proportion of patients after radiotherapy or combined treatments. One underlying reason might be a low efficacy of current treatments on eradication of cancer stem cells (CSCs). It has been recogni...

journal_title：Seminars in cancer biology

authors： Koch U,Krause M,Baumann M

更新日期：2010-04-01 00:00:00

abstract：:Ubiquitination plays a key role in regulating the tumour suppressor p53. It targets p53 for degradation by the 26S proteasome. The ubiquitin pathway also regulates the activity and localisation of p53. Ubiquitination requires ubiquitin-activating and -conjugating enzymes and ubiquitin ligases. In addition, ubiquitinat...

journal_title：Seminars in cancer biology

authors： Allende-Vega N,Saville MK

更新日期：2010-02-01 00:00:00

abstract：:We have found that not all Epstein-Barr viral (EBV) plasmids are duplicated each cell cycle. This inefficiency is intrinsic to EBV's mechanism of DNA synthesis in latently infected cells and necessarily leads to a loss of EBV plasmids from proliferating cells. If EBV provides its host cells advantages that allow those...

journal_title：Seminars in cancer biology

authors： Vereide D,Sugden B

更新日期：2009-12-01 00:00:00

abstract：:The study of polyomavirus has benefited immensely from two scientific methodologies, cell culture and in vitro studies on one side and the use of transgenic mice as experimental models on the other. Both approaches allowed us to identify cellular products targeted by the viruses, the consequences of these interactions...

journal_title：Seminars in cancer biology

authors： Sáenz Robles MT,Pipas JM

更新日期：2009-08-01 00:00:00

abstract：:Epigenetic alterations of the genome such as DNA promoter methylation and chromatin remodeling play an important role in tumorigenesis. Recent findings indicate epigenetic modifications as key factors in breast carcinogenesis. These modifications are quite appealing as targets for preventative care and therapeutics be...

journal_title：Seminars in cancer biology

authors： Dworkin AM,Huang TH,Toland AE

更新日期：2009-06-01 00:00:00

abstract：:Although chemokines and their receptors were initially identified as regulators of cell trafficking during inflammation and immune response, they have emerged as crucial players in all stages of tumor development, primary growth, migration, angiogenesis, and establishment as metastases in distant target organs. Neuroe...

journal_title：Seminars in cancer biology

authors： Gross N,Meier R

更新日期：2009-04-01 00:00:00

abstract：:Overt neoplasia is often the result of a chronic disease process encompassing an extended segment of the lifespan of any species. A common pathway in the natural history of the disease is the appearance of focal proliferative lesions that are known to act as precursors for cancer development. It is becoming increasing...

journal_title：Seminars in cancer biology

authors： Laconi E,Doratiotto S,Vineis P

更新日期：2008-10-01 00:00:00

abstract：:Hyaluronan is a megadalton glycosaminoglycan polymer critical for maintaining the integrity of the extracellular matrix. It can exist in a protein-bound state with aggregating proteoglycans, where it expands the extracellular matrix and modulates cell-cell interactions. It also exists in lower molecular weight forms t...

journal_title：Seminars in cancer biology

authors： Stern R

更新日期：2008-08-01 00:00:00

abstract：:Growing evidence supports the notion that pharmaceutical targeting of the 5-hydroxytryptamine (5-HT) and dopamine (DA) systems offers the potential to treat human immune system disorders. This review describes this emerging area of research, which has the benefit of being supported by a relatively detailed understandi...

journal_title：Seminars in cancer biology

authors： Barnes NM,Gordon J

更新日期：2008-06-01 00:00:00

abstract：:Recent empirical data have elucidated a compelling physiological basis for endogenously expressed, chemically authentic, morphine and its cognate mu3 and mu4 opiate receptors. Cellular "morphinergic" signaling is predominantly targeted to autocrine/paracrine regulatory processes and is reciprocally linked to stimulate...

journal_title：Seminars in cancer biology

authors： Stefano GB,Kream R

更新日期：2008-06-01 00:00:00

abstract：:The discovery of microRNAs (miRNAs) is one of the major scientific breakthroughs in recent years and has revolutionized the way we look at gene regulation. Although we are still at a very early stage in understanding their impact on immunity, miRNAs are changing the way we think about the development of the immune sys...

journal_title：Seminars in cancer biology

authors： Sonkoly E,Ståhle M,Pivarcsi A

更新日期：2008-04-01 00:00:00

abstract：:A key regulator of cell morphology is the actin cytoskeleton and it has long been appreciated that the cytoskeleton is characteristically altered in cancer. Actin is organized into polymeric structures with distinct dynamics which in turn participate in a wide variety of cell processes including adhesion, migration, c...

journal_title：Seminars in cancer biology

authors： O'Neill GM,Stehn J,Gunning PW

更新日期：2008-02-01 00:00:00

abstract：:Dietary flavonoids and other polyphenols show great potential as cancer chemopreventive agents in cell culture studies. This does not translate well into in vivo activity, because of extensive conjugative metabolism of these compounds in the intestine and liver. This paper presents a review of a flavonoid subclass in ...

journal_title：Seminars in cancer biology

authors： Walle T

更新日期：2007-10-01 00:00:00

abstract：:The processes of intraepithelial migration, intraluminal seeding, and field cancerization as models for initiation, spread, and recurrences of urothelial cell carcinoma (UCC) are reviewed in light of recent molecular investigations. The accumulated molecular data on synchronous and metachronous tumors indicate that th...

journal_title：Seminars in cancer biology

authors： Höglund M

更新日期：2007-06-01 00:00:00

abstract：:Cancer depends on cell death. It can emerge when cell death is deficient, and it could be treated through cancer-cell-specific induction of cell death. However, our understanding of cell death is still incomplete. While a few classical animal models have helped greatly in this respect, more may be learnt from non-clas...

journal_title：Seminars in cancer biology

authors： Golstein P

更新日期：2007-04-01 00:00:00

abstract：:Among unusual models to study cell death mechanisms, the protist Dictyostelium is remarkable because of its strategic phylogenetic position, with early emergence among eukaryotes and unicellular/multicellular transition, and its very favorable experimental and genetic flexibility. Dictyostelium shows developmental vac...

journal_title：Seminars in cancer biology

authors： Tresse E,Kosta A,Luciani MF,Golstein P

更新日期：2007-04-01 00:00:00

abstract：:DNA copy number amplifications activate oncogenes and are found in the majority of advanced solid tumors. Cell-lineage specificity and oncogene affinity of DNA amplifications in cancer suggest that properties of precursor stem cells and selection pressure in the tissue micro-environment determine the genomic location ...

journal_title：Seminars in cancer biology

authors： Myllykangas S,Böhling T,Knuutila S

更新日期：2007-02-01 00:00:00

abstract：:Chromosomal translocations and genomic instability are universal hallmarks of tumor cells. While the molecular mechanisms leading to the formation of translocations are rapidly being elucidated, a cell biological understanding of how chromosomes undergo translocations in the context of the cell nucleus in vivo is larg...

journal_title：Seminars in cancer biology

authors： Meaburn KJ,Misteli T,Soutoglou E

更新日期：2007-02-01 00:00:00

abstract：:Natural killer (NK) cells have important functions in the innate immunity to tumors. Recognition of tumor cells by NK cells is mediated by the interaction of activating and inhibitory NK cell receptors with ligands expressed on the tumor target. In addition, NK cell-target cell interactions require the engagement of a...

journal_title：Seminars in cancer biology

authors： Fuchs A,Colonna M

更新日期：2006-10-01 00:00:00

abstract：:Natural killer (NK) cells are important mediators of resistance against tumor growth and metastasis. NK cell reactivity is regulated by a balance of signals from activating and inhibitory receptors. While reactivity against tumor cells is beneficial, it is essential that NK cells do not attack normal tissue. The disti...

journal_title：Seminars in cancer biology

authors： Johansson MH,Höglund P

更新日期：2006-10-01 00:00:00

abstract：:There is sufficient evidence to suggest that tumor growth elicits specific immune responses, including CD8(+) and CD4(+) T cell responses that may delay tumor growth and could potentially be harnessed to eradicate cancer. Nevertheless the frequent outcome of cancer is lethality associated with uncontrolled growth and ...

journal_title：Seminars in cancer biology

authors： Khazaie K,von Boehmer H

更新日期：2006-04-01 00:00:00